Press

2024 Mutational Scanning Symposium

Q&A with JT Neal on Planning for the 2024 Mutational Scanning Symposium

New high-throughput method greatly expands view of how mutations impact cells

Broad scientists have developed a new approach for studying the functional effects of the millions of mutations associated with cancer and other diseases.

Mapping the effects of genetic variation, one letter at a time

A global project seeks to generate and analyze all possible variants of hundreds of protein-coding genes and learn how they might influence health and disease.

Organoid 2.0

To date, the development of co-culture systems of primary tumour epithelia incorporating additional cellular components, such as tumour-infiltrating lymphocytes (TILs), without artificial reconstitution has proven challenging. Now, Neal, Li et al. have successfully established patient-derived organoids (PDOs) of tumour epithelia retaining native immune cells, thereby recapitulating TME diversity.