We build and apply new approaches for understanding genome function from the level of individual DNA variants to complex disease biology.
Large scale DNA sequencing has transformed our ability to identify and catalog diverse genotypic information but created a new bottleneck: characterizing the impacts of genotype on human biology. Systematically connecting human genes and genotypes to disease- and trait-relevant phenotypes remains a grand challenge for biomedicine.
We combine high-throughput computational and experimental approaches in molecular biology, imaging, and single cell genomics to understand the connections between genetic variation, cellular functions, and disease biology.
“Genome: Bought the book; hard to read.” -Eric Lander
TECHNOLOgy development
We build and apply cutting-edge technologies for optical screening, single cell transcriptomics, genome editing, and disease model generation to enable scalable interrogation of biological processes driving disease.
“Progress in science depends on new techniques, new discoveries and new ideas, probably in that order.”
-Sydney Brenner, Nobel laureate
DISEASE AREAS
We take a “systems genomics” approach to tackle cancer, cardiometabolic disease, and rare genetic diseases. Our overall goal is to advance the translation of disease genetics into an understanding of underlying molecular and cellular disease mechanisms and identification of actionable therapeutic hypotheses.